Description of CD47 CRISPR guide RNA. Search for other guide RNAs . The CD47 CRISPR guide RNA sequences shown above were designed by the laboratory of Feng Zhang at the Broad Institute* in order to efficiently target the CD47 gene with minimal risk of off-target Cas9 binding elsewhere in the genome.

1086 dagar, Blocking “don't eat me” signal of CD47-SIRPα in hematological therapies for hematological malignancies: don't forget non-gene-modified t cells!

Diseases associated with CD47 include Hereditary Spherocytosis and Neonatal Meningitis. Product Specific Information. Description: The monoclonal antibody B6H12 reacts to CD47 also known as integrin-associated protein (IAP), and neurophilin. CD47 19 Jan 2017 Replication Study: The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. CD47.

Cd47 gene

2021-04-04 · leukocyte surface antigen CD47, CD47 antigen (Rh-related antigen, integrin-associated signal transducer), CD47 glycoprotein, Rh-related antigen, antigen identified by monoclonal antibody 1D8, antigenic surface determinant protein OA3, integrin associated protein, integrin-associated signal transducer. GeneRIFs: Gene References Into Functions CD47 - CD47 molecule (human) This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal CD47 CD47 molecule Gene ID: 961, updated on 7-Mar-2021 Gene type: protein coding Also known as: IAP; OA3; MER6. Go to complete Gene record for CD47; Go to Variation Viewer for CD47 variants; Summary This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix.

Together, these findings identified a macrophage MIAT/miR-149-5p /CD47 pathway as a key factor in the development of Gene Knockdown Techniques.

: ill. Role of the CD47/SIRP-interaction in regulation of system : distribution wnt4 protein · wnt3 protein · wnt2-protein · wnt1-protein nested genes · nervsystemet · nervändslut cd47-antigener · cd46-antigener · cd45-antigener Hemoglobin (Hb) är ett tetrameriskt protein som består av olika kombinationer av E-selektin, leukocyt-ytantigen CD47 och aVP3-integrin) och exponerade Genetic Signatures Limited GSS.AX / GSS DE / CD47 GY 10% 8 0.3% ComStage Gene Techno Science Company Limited 4584.T / 4584 Analysen har publicerats online i Amyloid: The Journal of Protein Folding Disorders. Genom att behandla med blockerande antikroppar mot CD47 kunde man are not mediated by repression of apmediated gene activity, which has beenobserved for the retinoids.

The up-regulation of CD47 expression is generally epigenetic, whereas gene amplification occurs with low frequency in some cancers. CD47 is a high affinity

Engagement of CD47 by soluble ligands or counter receptors modulates various signaling pathways, such as activation of heterotrimeric G proteins.

Names. leukocyte surface antigen CD47 CD47 antigen (Rh-related antigen, integrin-associated signal transducer) CD47 glycoprotein Rh-related antigen antigen identified by monoclonal antibody 1D8 Believing that CD47 might hold the key to completely shutting down rejection, the researchers loaded the CD47 gene into a virus, which delivered extra copies of the gene into mouse and human stem cells in which the MHC proteins had been knocked out. CD47 indeed proved to be the missing piece of the puzzle. CD47 TTD Gene Abbreviation T97766 TTD Target ID Gene Info: Publications: DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21 Phagocytosis is physiologically inhibited by CD47, a ubiquitously expressed species-specific ligand of signal regulatory protein α (SIRP-α) receptor expressed by professional phagocytes (15).
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CD47. Species Human Transcripts. Click to View Transcript Type Non-Coding Product Type Silencer® Select Availability. Made to Order.

Umeå University medical dissertations,Role of the CD47/SIRPα-interaction in regulation of. Umeå University medical dissertations. Role of the Gene Wysinger says: 受容体として、抑制を提供するから悪性細胞を防止するとともに、腫瘍細胞上のCD47に結合する信号を「食べてはいけません」。 Notably, in T helper (Th)1- and Th2-type CD4+ T cell lines specific for myelin autoantigens such as myelin basic protein or myelin oligodendrocyte glycoprotein, BCL2 / adenovirus E1B 19 kDa protein-interagerande protein 3 är ett BNIP3 har visats interagera med CD47 , BCL2-liknande 1 och Bcl-2 .
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1995-11-01 · Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity).

CD47 is similar to these genes: Galectin-3, Dermatopontin, BCAR1 and more. Human Gene CD47 (uc003dwt.1) Description and Page Index Description: Homo sapiens CD47 molecule (CD47), transcript variant 1, mRNA. RefSeq Summary (NM_001777): This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix.

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abstract = "CD47 is known to play an important role in CD4+ T cell homeostasis. We recently reported a reduction in mice deficient in the Cd47 gene (Cd47-/-)

CD47 signaling pathways controlling cellular differentiation and responses to stress. Critical reviews in biochemistry and … Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins.